1.加馬刀和電腦刀腦部及脊髓腫瘤立體定位放射手術
2.巴金森症及頑固型疼痛之治療
3.脊椎神經和週邊神經損傷修補手術

1.以加馬刀及電腦刀治療腦內頸動脈海綿竇婁管、腦下垂體瘤、轉移性腦瘤、動靜脈血管畸形、腦膜瘤、聽神經瘤、腦血管瘤、不自主動作、癲癇症及三叉神經痛等疾病並有專業性論著
2.發展使用許旺細胞及骨髓單核球細胞治療橈神經,尺神經,正中神經損傷及臂神經叢損傷
3.開發立體定位儀及立體定位手術的校正空間誤差的方法

曾任：
美國維吉尼亞大學附設醫院進修加馬刀手術及不自主運動之治療
中華民國神經外科醫學會 專科醫師
台北榮總 神經外科 總醫師
台北榮總 住院醫師
現任：台灣立體定位功能神經外科及放射手術醫學會理事長
醫學研究部基礎醫學研究科主任

國立陽明醫學院醫學系畢業
國立嘉義大學EMBA畢業
國立中興大學博士畢業

台灣神經外科醫學會 專科醫師
中華民國外科醫學會 專科醫師

國立中興大學生命科學院轉譯醫學學程博士班兼任教授

1.立體定位放射手術治療功能性疾病三叉神經痛,巴金森氏症及精神疾病等療效和併發症的研究
2.使用許旺細胞及單核球細胞用於治療週邊神經壓傷的展望
3.神經幹細胞之臨床應用
4.發展立體定位儀及腦導航係统

1.使用特化的單核球細胞的移植在神經接合手術的效益
2.探討巨大顱內動靜脈血管畸形使用單次及多次治療的療效評估
3.應用用高光譜在神經痛的預測
4.研究飲食的控制在周邊神經損傷的預防效益及機轉
5.研究中樞神經發炎下，微膠細胞透過芳香烴受體和核因子類胡蘿蔔素2相關因子2的關係
6.研究腦室內出血和永久性腦室腹膜腔分流手術的關鍵因素

Melatonin Enhanced Microglia M2 Polarization in Rat Model of Neuro-inflammation Via Regulating ER Stress/PPARδ/SIRT1 Signaling Axis
Hung-Chuan Pan(第一作者), Cheng-Ning Yang, Wen-Jane Lee, Jason Sheehan, Sheng-Mao Wu, Hong-Shiu Chen, Mao-Hsun Lin, Li-Wei Shen, Shu-Hua Lee, Chin-Chang Shen, Liang-Yi Pan, Shing‑Hwa Liu & Meei-Ling Sheu Journal of Neuroimmune Pharmacology (2024) 19:11 https://doi.org/10.1007/s11481-024-10108-y
Targeting histone deaectylase-3 blocked epithelial-mesenchymal plasticity and metastatic dissemination in gastric cancer
Wu SM, Jan YJ, Tsai SC, Pan HC#, Shen CC, Yang CN, Lee SH, Liu SH, Shen LW, Chiu CS, Arbiser JI, Men M, Sheu ML. (並列第一作者)Cell Biol Toxicol. (2023) 39:1873–1896
Neuronal Death Caused by HMGB1-Evoked via Inflammasomes from Thrombin-Activated Microglia Cells
Sheu ML, Pan LY, Yang CN, Sheehan J, Pan LY, You WC, Wang CC, Chen HS, Pan HC(通訊作者). Int J Mol Sci. 2023, 24, 12664. https://doi.org/10.3390/ijms241612664
Thrombin induced microglia activation modulated through aryl hydrocarbon receptors
Sheu ML, Pan LY, Yang CN, Sheehan J, Pan LY, You WC, Wang CC, Pan HC(通訊作者).
Int J Mol Sci. 2023, 24, 11416. https://doi.org/10.3390/ijms241411416.
TPL2 aids gastric cancer cell proliferation and chemoresistance through intensifying hypoxia/PPARd axis.
Lan KL, De-Wei Lai DW, Yang CN, Pan HC((並列第一作者), Ou HT, Huang ZT, Chou KL, Wu SM, Shen LW, Shen CC, Chen L, Liu SH, Chiu CS, Arbiser JL and Sheu ML .
British Journal of Pharmacology 2023(accepted)
Re-irradiation combined with bevacizumab for recurrent glioblastoma beyond bevacizumab failure: survival outcomes and prognostic factors.
You WC, Lee HD, Pan HC(並列第一作者), Chen HC.
Sci Rep. 2023 Jun 9;13(1):9442. doi: 10.1038/s41598-023-36290-2.PMID: 37296207
Using the deformity index of vital structures to predict outcome of patients with large vestibular schwannomas after Gamma Knife radiosurgery.
Chang HC, You WC, Shen CC, Chen YJ, Sun MH, Sheu ML, Pan LY, Sheehan J, Su KC, Pan HC(通訊作者).J Neurooncol. 2023 Mar;162(1):179-189. doi: 10.1007/s11060-023-04280-z. Epub 2023 Mar 9.PMID: 36894719
Potential Therapeutic Effects of Thiazolidinedione on Malignant Glioma.
Sheu ML, Pan LY, Hu HY, Su HL, Sheehan J, Tsou HK, Pan HC(通訊作者).
Int J Mol Sci. 2022 Nov 4;23(21):13510. doi: 10.3390/ijms232113510.PMID: 36362294
Influence of COVID-19 pandemic on the decision making of patients in undergoing gamma knife radiosurgery.
Shen CC, Jiang RS, Yang MY, You WC, Sun MH, Sheu ML, Pan LY, Sheehan J, Pan HC (通訊作者).
Eur J Med Res. 2022 Oct 29;27(1):223. doi: 10.1186/s40001-022-00859-w.PMID: 3630970
Modulation of ary hydrocarbon receptor expression alleviated neuropathic pain in a chronic constriction nerve injury model
Sheu ML, Pan LY, Sheehan J, Yang MY, Pan HC (通訊作者)
Int. J. Mol. Sci. 2022, 23,11255. https://doi.org/10.3390/ijms231911255
Gamma knife radiosurgery for indirect dural carotid cavernous fistula:Long term ophthalmological outcome
Shen CC, Pan LY, Tsuei YS, Yang MY, You WC, Sun MH, Sheu ML, Pan LY, Sheehan J, Pan HC (通訊作者)Life 12(8), 1175, 2022
Aggravation of pulmonary fibrosis after knocking down the aryl hydrocarbon receptor in the insulin-like growth factor 1 receptor pathway
Wu SM, Tsai JJ, Pan HC, Arbister J, Leonardo E, Sheu ML. (並列第一作者)
British Journal of Pharmacology 2022,179:3430–3451

Sequence-specific targeting of Caenorhabditis elegans C-Ala
to the D-loop of tRNAA
Antika TR, Nazilah KR, Chrestella DJ, Wang TL, Tseng YK, Wang SC, Hsu HL, Wang SW, Chuan TH, Pan HC(共同作者), Horng JC, Wang CC.J. Biol. Chem. (2023) 299(9) 105149
Federated Learning: A Cross-Institutional Feasibility Study of Deep Learning Based Intracranial Tumor Delineation Framework for Stereotactic Radiosurgery.
Lee WK, Hong JS, Lin YH, Lu YF, Hsu YY, Lee CC, Yang HC, Wu CC, Lu CF, Sun MH, Pan HC(共同作者), Wu HM, Chung WY, Guo WY, You WC, Wu YT
J Magn Reson Imaging. 2023 Aug 12. doi: 10.1002/jmri.28950. Online ahead of print.PMID: 37572087
Deep Learning Detection and Segmentation of Brain Arteriovenous Malformation on Magnetic Resonance Angiography.
Hong JS, You WC, Sun MH, Pan HC(共同作者), Lin YH, Lu YF, Chen KM, Huang TH, Lee WK, Wu YT.
J Magn Reson Imaging. 2023 May 23. doi: 10.1002/jmri.28795. Online ahead of print.PMID: 3722019
Dual regeneration of muscle and nerve by intramuscular infusion of mitochondria in a nerve crush injury model.
Sheu ML, Shen CC, Tsou HK, Yang MY, Su HL, Sheen J, Chang MH, Chen HS, Pan HC* (通訊作者) Neurosurgery. 2021 Jun 15;89(1):E49-E59. doi: 10.1093/neuros/nyab105.
Outcome of intracerebral cavernoma treated by gamma knife radiosurgery based on double blind assessment of treatment indication
She CC, Sun MH, Yang MY, You WC, Sheu ML, Chen YJ, Chen YJ, Sheehan J, Pan HC* (通訊作者)
Radiat Oncol 2021 August 28; 16(1):164. doi: 10.1186/s13014-021-01885-4.PMID: 34454542
Efficacy of percutaneous endoscopic lumbar discectomy for pediatric lumbar disc herniation and degeneration on magnetic resonance imaging: case series and literature review.
Lin RH, Chen HC, Pan HC, Chen HT, Chang CC, Tzeng CY, Chen TY, Tsou HK(共同作者).
J Int Med Res. 2021 Jan;49(1):300060520986685. doi: 10.1177/0300060520986685.PMID: 3347247
Increased angiogenesis by the rotational muscle flap is crucial for nerve regeneration.
Pan HC*, Chang MH, Sheu ML, Chen CJ, Sheehan J. (第一作者及通訊作者)
PLoS One. 2019 Jun 10;14(6):e0217402. doi: 10.1371/journal.pone.0217402. eCollection 2019.
Down-Regulated Expression of Magnesium Transporter Genes Following a High Magnesium Diet Attenuates Sciatic Nerve Crush Injury.
Chen YJ, Cheng FC, Chen CJ, Su HL, Sheu ML, Sheehan J, Pan HC*.(通訊作者)
Neurosurgery. 2019 Apr 1;84(4):965-976. doi: 10.1093/neuros/nyy120.
Intrathecal Injection of Dual Zipper Kinase shRNA Alleviating the Neuropathic Pain in a Chronic Constrictive Nerve Injury Model.
Sheu ML, Chiang CY, Su HL, Chen CJ, Sheehan J, Pan HC*.(通訊作者)
Int J Mol Sci. 2018 Aug 16;19(8). pii: E2421. doi: 10.3390/ijms19082421
Late administration of high-frequency electrical stimulation increases nerve regeneration without aggravating neuropathic pain in a nerve crush injury
Su HL, Chiang CY, Lu ZH, Cheng FC, Chen CJ, Sheu ML , Sheehan J, Pan HC*.(通訊作者)
BMC Neurosci. 2018 Jun 25;19(1):37. doi: 10.1186/s12868-018-0437-9.
Outcome of partially irradiated recurrent nonfunctioning pituitary macroadenoma by
Gamma Knife radiosurgery.
Shen CC, You YC, Sun MH, Lee SD, Tsou HK, Chen YJ, Sheu ML, Sheehan J, Pan HC*.(通訊作者)
J Neurooncol. 2018 Sep;139(3):767-775. doi: 10.1007/s11060-018-2925-2. Epub 2018 Jun 13.

2023獲得第一屆煦陽溫和大地優良醫學論文獎醫師組第一名
2020,2023及2024年獲得國際外科學術論文獎