消化內科學、胃腸蠕動生理病理學

消化潰瘍、肝炎、肝硬化、肝癌、胃腸蠕動異常

臺中榮總醫療副院長(2015/3~2021)
臺中榮總內科部部主任(2012/10~2015/3)
臺中榮總胃腸肝膽科主任(2007/1~2012/10)
臺中榮總內視鏡診斷及治療中心主任(2006~)
Cedars-Sinai Medical Center進修(1992-1993)
臺中榮總胃腸科主治醫師(1989/7~)
臺中榮總內科部總醫師(1987/6~1989/6)
臺中榮總內科部住院醫師(1984/6~1987/6)
台灣胃腸神經與蠕動學會創會理事長

中山醫學大學醫學研究所醫學博士(2007-2010)
高雄醫學大學醫學系(1975/9~1982/6)

臺灣內科醫學會 (2017)
臺灣消化醫學會 (343)
中華民國內視鏡醫學會 (226)
中華民國靜脈暨腸道營養醫學會 (399)

中山醫學大學副教授 2000/ 6 (副字第027189)

Cedars-Sinai Medical Center, Los Angeles, CA,
USAResearch Fellow of Clinical GI Motility, 1992-1993

消化潰瘍、幽門螺旋桿菌、胃腸蠕動生理病理學

睡眠障礙對質子幫浦阻斷劑治療胃食道逆流疾病患者生活品質之影響

1.Chang LC, Huang TH, Chang CS, Tsai YR, Lin RH, Lee PW, Hsu MF, Huang LJ, JWang JP. Signaling mechanisms of inhibition of phospholipase D activation by CHS-111 in formyl peptide-stimulated neutrophils. Biochem Pharmacol. 2011 Jan 15;81(2):269-78.
2.Lien HC, Wang JY, Hsu FC, Sung KF, Cheng WM, Liang HW, Chang CS*. Classical reflux symptoms, hiatus hernia and overweight independently predict pharyngeal acid exposure in Taiwanese patients with suspected reflux laryngitis. Aliment Pharmacol Ther. 2011 Jan;33(1):89-98.
3.Lee SW, Yeh HZ, Chang CS. Calcifying fibrous pseudotumor of the esophagus. J Chin Med Assoc. 2010 Nov;73(11):599-601.
4.Peng YC, Tung CF, Chow WK, Chen SY, Chang CS. Factors Contributing to the Failure of Argon Plasma Coagulation Hemostasis in Patients with Nonvariceal Upper Gastrointestinal Tract Bleeding. Hepato-gastroenterology 2010; 57(101): 781-786.
5.Chang CS, Ko CW, Lien HC, Chou MC. Effect of Electroacupuncture on St. 36 (Zusanli) and LI. 10 (Shousanli) Acupuncture Points on Heart Rate Variability. Am J Chinese Medicine 2010; 38(2): 231-239.
6.Chang CS, Ko CW, Lien HC, Chou MC. Varying postprandial abdominovagal and cardiovagal activity in normal subjects. Neurogastroenterol Motil. 2010 May;22(5):546-551, e119.
7.Ho HH, Chang CS#, Ho WC, Liao SY, Wu CH, Wang CJ. Anti-metastasis Effects of Gallic Acid on Gastric Cancer Cells Involves inhibition of NF-κB activity and downregulation of PI3K/AKT/small GTPase signals. Food Chem Toxicol 2010 Aug-Sep;48(8-9):2508-16.
8.Cheng HH, Chang CS#, Wang HJ, Wang WC. IL-1β and IL-10 polymorphisms influence erosive reflux esophagitis and gastritis in Taiwanese patients. J Gastroenterol Hepatol 2010 Aug;25(8):1443-51.
9.Lee SW, Chang CS, Lee TY, Yeh HZ, Tung CF, Peng YC. Risk factors and therapeutic response in Chinese patients with peptic ulcer disease. World J Gastroenterol. 2010 Apr 28;16(16):2017-22.
10.Lee SW, Chang CS, Lee TY, Tung CF, Peng YC. The role of the Tokyo guidelines in the diagnosis of acute calculous cholecystitis. J Hepatobiliary Pancreat Sci. 2010 Nov;17(6):879-84.
11.Lee SW, Lien HC, Chang CS. Tuberculous liver abscess in a case without lung involvement. Kaohsiung J Med Sci. 2010 Feb;26(2):99-104.
12.Lee SW, Lee TY, Chang CS*, Ko CW, Yeh HZ, Yang SS. Independent Factors Associated With Early Outcome in Chinese Cirrhotic Patients After Cessation of Initial Esophageal Variceal Hemorrhage. J Clin Gastroenterol. 2010 Jul;44(6):e123-7.
13.Lee TY, Yeh HZ, Yang SS, Chang CS*. Successful Application of Hemoclips plus Argon Plasma Coagulation for Angioectasia Bleeding with Underlying Arteriovenous Malformation in the Colon. Colorectal Dis. Colorectal Dis. 2010 Jul;12(7 Online):e180-1.
14.Lee SW, Yang SS, Chang CS, Yeh HJ. Impact of the Tokyo guidelines on the management of patients with acute calculous cholecystitis. J Gastroenterol Hepatol 2009; 43(12): 1857-1861.
15.Lee SW, Lee TY, Yeh HZ, Chang CS, Wang RC. An Unusual Case of Metastatic Small Intestinal Tumor Due to Prostate Cancer. J Chin Med Assoc 2009; 72(5): 271 – 274.
16.Lee SW, Lee TY, Chang CS. Independent factors associated with recurrent bleeding in cirrhotic patients with esophageal variceal hemorrhage. Dig Dis Sci. 2009 May;54(5):1128-34.
17.Lee SW, Yang SS, Chang CS, Yeh HJ, Chow WK. Mycoplasma pneumonia-associated Acute Hepatitis in an Adult Patient without Lung Infection. J Chin Med Assoc 2009;72(4):204-6.
18.Lu IT, Ko CW, Chang CS, Hou TC. Asymptomatic intussusception secondary to a giant appendiceal mucocele treated via a laparoscopic approach. Gastrointestinal Endoscopy, Gastrointest Endosc. 2009;70(5):1026-1027.
19.Lien HC, Chang CS, Yeh HZ, Ko CW, Chang HY, Cheng KF, Sung FC. Increasing Prevalence of Erosive Esophagitis Among Taiwanese Aged 40 Years and Above: A Comparison Between Two Time Periods. J Clin Gastroenterol. 2009; 43(10 ): 926-932.
20.Liu PF, Chang CS, Wang J, Wu CC, Yeh HZ. Primary gastric tuberculosis. Endoscopy. 2009;41 Suppl 2:E327-8.

21.Chang LC, Lin RH, Huang LJ, Chang CS, Kuo SC, Wang JP. Inhibition of superoxide anion generation by CHS-111 via blockade of the p21-activated kinase, protein kinase B/Akt and protein kinase C signaling pathways in rat neutrophils. Eur J Pharmacol. 2009 Aug 1;615(1-3):207-17.
22.Shu KH, Chang CS, Chuang YW, Chen CH, Cheng CH, Wu MJ, Yu TM. Intestinal bacterial overgrowth in CAPD patients with hypokalaemia. Nephrol Dial Transplant 2009;24(4):1289-92.
23.Chuang JY, Yang SS, Lu YT, Hsieh YY, Chen CY, Chang SC, Chang CS, Yeh HZ, Kao JH. IL-10 promoter gene polymorphisms and sustained response to combination therapy in Taiwanese chronic hepatitis C patients. Dig Liver Dis. 2009 Jun;41(6):424-30.
24.Poon SK, Lai CH, Chang CS, Lin WY, Chang YC, Wang HJ, Lin PH, Lin HJ, Wang WC. Prevalence of antimicrobial resistance in Helicobacter pylori isolates in Taiwan in relation to consumption of antimicrobial agents. Int J Antimicrob Agents. 2009;34(2):162-5.
25.Wang SW, Chang CS, Wang J, Yeh HZ. Early adenocarcinoma originating in submucosal gland of thoracic esophagus presenting as submucosal tumor. Endoscopy 2008;40 Suppl 2:E237-8.
26.Chang LC, Tsao LT, Chang CS, Chen CJ, Huang LJ, Kuo SC, Lin RH, Wang JP. Inhibition of nitric oxide production by the carbazole compound LCY-2-CHO via blockade of activator protein-1 and CCAAT/enhancer-binding protein activation in microglia. Biochem Pharmacol. 2008 Aug 15;76(4):507-
27.Lin CS, Tung CF, Yeh HZ, Chang CS, Lin CW. Aortoesophageal fistula with a history of graft treatment for thoracic aortic aneurysm. J Chin Med Assoc. 2008 Feb;71(2):100-2.
28.Lin CS, Tung CF, Peng YC, Chow WK, Chang CS, Hu WH. Successful treatment with a combination of endoscopic injection and irrigation with coca cola for gastric bezoar-induced gastric outlet obstruction. J Chin Med Assoc. 2008 Jan;71(1):49-52.
29.Lin CS, Chang CS, Yang SS, Yeh HZ, Lin CW. Retrospective evaluation of serum markers APRI and AST/ALT for assessing liver fibrosis and cirrhosis in chronic hepatitis B and C patients with hepatocellular carcinoma. Intern Med. 2008;47(7):569-75.
30.Wu CY, Wu MS, Chen YJ, Chen HP, Chen CJ, Chang CS, Lin JT. Clinicopathological significance of urokinase-type plasminogen activator genotypes in gastric cancer Hepatogastroenterology. 2008 Sep-Oct;55(86-87):1890-4.
31.Lee TY, Lien HC, Chang CS, Wen MC. Barrett’s Esophagus and Severe Reflux Esophagitis Share Common Pathophysiological Characteristics among Chinese in Taiwan. Intern Med. 2008;47(20):1767-73.
32.Lee TY, Chan T, Chang CS, Lan JL. Introducing a clinical pathway for acute peptic ulcer bleeding in general internal medicine wards. Scand J Gastroenterol. 2008;43(10):1169-76.
33.Chang CS, Huang SM, Lin HH, Wu CC, Wang CJ. Different expression of apoptotic proteins between HBV-infected and non-HBV-infected hepatocellular carcinoma. Hepatogastroenterology. 2007 Oct-Nov;54(79):2061-8.
34.Tung CF, Chow WK, Chang CS, Peng YC, Hu WH. The prevalence and significance of hypoalbuminemia in non-variceal upper gastrointestinal bleeding. Hepatogastroenterology 2007;54(76):1153-6.
35.Kuo MJ, Yeh HZ, Chen GH, Poon SK, Yang SS, Lien HC, Chang CS. Improvement of tissue-adhesive obliteration of bleeding gastric varices using adjuvant hypertonic glucose injection: a prospective randomized trial. Endoscopy 2007;39(6):487-91.
36.Peng YC, Hsu CL, Tung CF, Hong DZ, Chow WK, Chang CS, Chen GH. Reactive Oxygen Species of Gastric Antral Mucosa in Patients with Peptic Ulcer Disease. Gastroenterol J Taiwan 2007;24 ; 255-262.
37.Liao SC, Ko CW, Yeh HZ, Chang CS, Yang SS, Chen GH. Successful treatment of persistent bacteremia after endoscopic injection of N-butyl-2-cyanoacrylate for gastric varices bleeding. Endoscopy. 2007 Feb;39 Suppl 1:E176-7.

38.Yang SS, Fu LS, Chang CS, Yeh HZ, Chen GH, Kao JH. Changes of soluble CD26 and CD30 levels correlate with response to interferon plus ribavirin therapy in patients with chronic hepatitis C. J Gastroenterol Hepatol. 2006 Dec;21(12):1789-93.
39.Ko CW, Chang CS*. Inlet patch: an inconspicuous lesion needs more spotlight. South Med J. 2006 Aug;99(8):798.
40.Lai CH, Kuo CH, Chen PY, Poon SK, Chang CS*, Wang WC. Association of antibiotic resistance and higher internalization activity in resistant Helicobacter pylori isolates. J Antimicrob Chemother. 2006 Mar;57(3):466-71.