跳到主要內容區塊
:::醫學研究部 > 公開資訊 > 轉譯醫學研究科 > 計算生物學中心

近期研究著作

引用 (8)
更新日期 2024/5/21 8:29:04
點閱 3370

【SCI paper】 (* corresponding author) (2018-2024)
 

編號
論文發表
1 Hsu YC, Chiu YC, Lu TP, Hsiao TH*, Chen Y*. (2024) Predicting drug response through tumor deconvolution by cancer cell lines. Patterns 2024 Mar, https:// doi.org/10.1016/j.patter.2024.100949.
2 Chung CW, Chou SC, Hsiao TH, Zhang GJ, Chung YF, Chen YM*. (2024) Machine learning approaches to identify systemic lupus erythematosus in anti-nuclear antibody-positive patients using genomic data and electronic jealth records. BioData Min. 2024 Jan 5; 17(1):1. doi: 10.1186/s13040-023-00352-y.
3 Yeh TT, Chen IC, Cho S, Chang TG, Shih KH, Hua MW, Li JL, Hsu CY, Hsiao TH*, Chen YM. GJB2 p. V37I Mutation Associated With Moderate Nonsyndromic Hearing Loss in an Adult Taiwanese Population. Ear Hear.  2023 Nov-Dec;44(6):1423-1429. doi: 10.1097/AUD.0000000000001384. Online ahead of print. 3.652 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY 1/33 3x6x5=90
4 Liao YJ1, Chen YT1, Hsiao TH, Lin CH, Wu MF, Hsu CY, Chen YM*, Hsu CS*. (2023) CYP2C19 genotypes and osteoporotic fractures in long-term users of proton pump inhibitors: A hospital-based study. Clin Transl Sci. 2023Nov; 16(11): 2198–2208. doi: 10.1111/cts.13620. Online ahead of print.
5 Jiang RS, Chen IC, Chen YM, Hsiao TH, Chen YC*. (2023) Risk prediction of chronic rhinosinusitis with or without nasal polups in Taiwanese population using polygenic risk score for nasal polyps. Biomedicines. 2023 Oct 9; 11(10): 2729.  doi: 10.3390/biomedicines11102729.
6 Teng LC, Liao YM, Gau JP, Hsiao TH, Chen TC, Chen MH, Yeh SP, Teng CL. (2023) Clinical features and outcomes of primary breast diffuse large B-cell lymphoma: A matched-pair study. Clin Med Insights Oncol. 2023 Oct 28; 17: 11795549231203142. doi: 10.1177/11795549231203142.
7 Lee WJ, Chuang HN, Hsiao TH, Lee WL, Wu JP, Sheu WH, Liang KW*. (2023) Prevalence and prognosis of genetically proven familial hypercholesterolemia in subjects with coronary artery disease and reduced ejection fraction. Sci Rep. 2023 Oct 7; 13(1): 1692. doi: 10.1038/s41598-023-44065-y.
8 Cheng PL, Hsiao TH, Chen CH, Hung MN, Jhan PP, Lee LW, Wu TS, Tsai JR, Teng CL*. (2023) Chemoresistance in acute myeloid leukemia: An alternative single-cell RNA sequencing approach. Hematol Oncol. 2023 Aug; 41(3): 499-509. doi: 10.1002/hon.3129. Epub 2023 Feb 25.
9 Chattopadhyay A, Lee CY, Shen YC, Lu KC, Hsiao TH, Lin CH, Lai LC, Tsai MH, Lu TP*, Chuang EY*. Multi-ethnic Imputation System (MI-System): A genotype imputation server for high-dimensional data. J Biomed Inform. 2023 Jun 10; 143: 104423. doi: 10.1016/j.jbi.2023.104423. Online ahead of print.
10 Chang YL, Hsiao TH, Wu MF, Chen CH*. (2023) The Prevalence and Features of Medications With Actionable Pharmacogenomic Biomarkers Prescribed to Kidney Transplant Recipients. Transplant Proc. 2023 Apr 29; S0041-1345(23)00222-1.
11 Jiang RS, Lin HJ, Wei CY, Hsiao TH*. (2023) Genetic variations in bitter and sweet taste receptors in Taiwanese patients with chronic rhinosinusitis. Int Forum Allergy Rhinol. 2023 Mar; 13(3): 265-268. 5.462 OTORHINOLARYNGOLOGY 2/62 3x6x5=90
12 Chih CH1, Chuang HK1, Hsiao TH, Yang YP, Gao CE, Chiou SH, Hsu CC*, Hwang DK*. (2023) Genome-wide association study and identification of systemic comorbidities in development of age-related macular degeneration in a hospital-based cohort of Han Chinese. Front Genet. 2023 Feb 24; 14: 1064659. 4.772 GENETICS & HEREDITY 56/191 3x4x5*0.6=36
13 Chen IC, Chen HH, Jiang YH, Hsiao TH, Ko TM, Chao WC. (2023) Whole transcriptome analysis to explore the impaired immunological features in critically ill elderly patients with sepsis. J Transl Med. 2023 Feb 23; 21(1): 141.
14 Chang TG, Yeh TT, Wei CY, Hsiao TH*, Chen IC*. (2023) Impacts of ADH1B rs1229984 and ALDH2 rs671 polymorphisms on risks of alcohol-related disorder and cancer.  Cancer Med. 2023 Jan; 12(1): 747-759. 4.711 ONCOLOGY114/318 3x4x5*0.9=54
15 Lu TJ1, Hsiao TH, Wang JD, Lo FC, Jhan PP, Chen WC*. (2023) Perinatal lethal Gaucher disease due to compound heterozygosity of thw splicing mutations in GBA gene. Taiwan J Obstet Gynecol. 2023 Jan; 62(1): 175-178. (case report).
16 Lin HJ1, Chuang HN1, Jhan PP, Ye HY, Lee IT*, Hsiao TH*, Liu PY*. (2023) Pyuria Is Associated with Dysbiosis of the Urinary Microbiota in Type 2 Diabetes Patients Receiving Sodium–Glucose Cotransporter 2 Inhibitors. Microbiol. Res. 2023, 14: 34-41. 5.070 MICROBIOLOGY43/158 3x4x5*0.6=36
17 Tung H, Lin CH, Chen YM, Le WJ, Chien LS, Sun TH, Liao CS, Lin YY*, Hsiao TH*. (2022 Dec) Utilizing apolipoprotein E genotypes and associated comorbidities for the assessment of the risk for dementia. Frontiers in Aging Neuroscience 2022 Dec 12, DOI 10.3389/fnagi.2022.927656. 5.702 NEUROSCIENCES96/306 3x4x5*0.9=54
18 Jiang RS1, Chih CH1, Jiang YH, Hsieh HH, Chiang YF, Chuang HN*, Hsiao TH*. (2022 Nov) Nasal mycology of chronic rhinosinusitis revealed by nanopore sequencing. Diagnostics. 2022 Nov 9; 12: 2735. 3.992 MEDICINE, GENERAL & INTERNAL65/329 3x5x5*0.9=67.5
19 Lin CH1, Chuang HN1, Hsiao TH, Kumar VB, Hsu CH, Huang CY, Lee LW, Mao CL, Ko JL*, Hsu CP*. AGR2 expression as a predictive biomarker for therapy response in esophageal squamous cell carcinoma. PLoS One. 2022 Nov 3; 17(11): e0276990.
20 Chen YJ, Chen IC, Chen YM, Hsiao TH, Wei CY, Chuang HN, Lin WW*, Lin CH*. (2022 Sep) Prevalence of genetically defined familial hypercholesterolemia and the impact on acute myocardial infarction in Taiwanese population: A hospital-based study. Front Cardiovasc Med. 2022 Sep 12;9:994662. doi: 10.3389/fcvm.2022.994662. eCollection 2022.
21 Chen YW, Liao YJ, Chang WJ, Hsiao TH, Lin CH, Hsu CY, Liu TJ, Lee WL, Chen YM. (2022 Aug) CYP2C19 loss-of-function alleles predicts clinical outcomes in East Asian patients with acute myocardial infarction undergoing percutaneous coronary intervention and stenting receiving clopidogrel. Front Cardiovasc Med. 2022 Aug 22;9:994184. doi: 10.3389/fcvm.2022.994184. eCollection 2022.
22 Chen YJ, Cheng PL, Huang WH, Chen HH, Chen HW, Chen JP, Lin CT, Tang KT, Hung WT, Hsieh TY, Chen YH, Chen YM*, Hsiao TH*. (2022 Aug) Single-cell RNA sequencing to decipher the immunogenicity of ChAdOx1 nCoV-19/AZD1222 and mRNA-1273 vaccines in patients with autoimmune rheumatic diseases. Front Immunol. 2022 Aug 1;13:920865. doi: 10.3389/fimmu.2022.920865. eCollection 2022. 8.787 IMMUNOLOGY43/178 3x8.787x5=131.8
23 Chang TG, Yen TT, Wei CY, Hsiao TH*, Chen IC*.  (2022 Jun) Impacts of ADH1B rs1229984 and ALDH2 rs671 polymorphisms on risks of alcohol-related disorder and cancer. Cancer Med. 2022 Jun 6. doi: 10.1002/cam4.4920. Online ahead of print. 4.711 ONCOLOGY114/318 3x4x5*0.9=54
24 Chuang HN1, Shih CH1, Tsai HW, Jiang RS, Hsiao TH, Liu PY, Jan YJ, Wang JM*. (2022 May) Laboratory Surge Response to the COVID-19 Pandemic: An Incident Command System Approsch. J Multidiscip Healthc. 2022 May 11; 15: 1083-1088. doi: 10.2147/JMDH.S358096. eCollection 2022.
25 Yang WT, Huang WH, Liao TL, Hsiao TH, Chuang HN, Liu PY*. (2022 Feb) SARS-CoV-2 E484K Mutation Narrative Review: Epidemiology, Immune Escape, Clinical Implications, and Future Considerations. Infect Drug Resist. 2022 Feb 3;15:373-385. doi: 10.2147/IDR.S344099. eCollection 2022.
26 Huang CC, Lee LH, Lin WS, Hsiao TH, Chen IC, Lin CH*. (2022 Feb) The Association between Bodily Pain and Cognitive Impairment in Community-Dwelling Older Adults. J Per Med. 2022 Feb 25; 12(3): 350. doi: 10.3390/jpm12030350.
27 Liao YJ, Hsiao TH, Lin CH, Hsu CS, Chang YL, Chen YW, Hsu CY, Chen YM*, Wu MF*. (2022 Feb) Clopidogrel Use and CYP2C19 Genotypes in Patients Undergoing Vascular Intervention Procedure: A Hospital-Based Study. Pharngenomics Pers Med. 2022 Feb 2; 15: 81-89. doi: 10.2147/PGPM.S335860. eCollection 2022.
28 Chung CW, Hsiao TH, Huang CJ, Chen YJ, Chen HH, Lin CH, Chou SC, Chem TS, Chung YF, Yang HI, Chen YM*. (2021 Dec) Machine learning approaches for the genomic prediction of rheumatoid arthritis and systemic lupus erythematosus. BioData Min. 2021 Dec 11; 14(1): 52. doi: 10.1186/s13040-021-00284-5.
29 Cheng PL, Chen HH, Jiang YH, Hsiao TH, Wang CY, Wu CL, Ko TM, Chao WC*. (2021 Dec) Using RNA-Seq to Investigate Immune-Metabolism Features in Immunocompromised Patients With Sepsis. Front Med (Lausanne). 2021 Dec 17; 8: 747263. doi: 10.3389/fmed.2021.747263. eCollection 2021.
30 Chi JT, Ipsen IC, Hsiao TH, Lin CH, Wang LS, Lee WP, Lu TP, Tzeng JY*. (2021 Nov) SEAGLE: A Scalable Exact Algorithm for Large-Scale Set-Based Gene-Environment Interaction Tests in Biobank Data. Front Genet. 2021 Nov 2; 12: 710055. doi:  10.3389/fgene.2021.710055. eCollection 2021. 4.772 GENETICS & HEREDITY 56/191
31 Chiu PC1, Chattopadhyay A1, Wu MC, Hsiao TH, Lin CH, Lu TP*. Elucidation of a Causal Relationship Between Platelet Count and Hypertension: A Bi-Directional Mendelian Randomization Study. (2021 Nov) Front Cardiovasc Med. 2021 Nov 26; 8: 743075. doi: 10.3389/fcvm.2021.743075. eCollection 2021.
32 Yeh TT, Chen IC, Hua MW, Wei CY, Shih KH, Li JL, Lin CH, Hsiao TH, Chen YM*, Jiang RS*. (2022 Oct) A KCNQ4 c.546C>G Genetic Variant Associated with Late Onset Non-Syndromic Hearing Loss in a Taiwanese Population. Genes (Basel). 2021 Oct 27; 12(11): 1711. doi: 10.3390/genes12111711.
33 Sun TH, Shao YH, Mao CL, Hung MN, Lo YY, Ko TM, Hsiao TZ*. (2021 Oct) A Novel Quality-Control Procedure to Improve the Accuracy of Rare Variant Calling in SNP Arrays. Frontiers in Genetics, 2021 Oct.12: 736390.  doi: 10.3389/fgene.2021.736390. 4.772GENETICS & HEREDITY 56/191 3x4x5=60
34 Lee WJ, Chuang HN, Chen YM, Liang KW, Tung H, Chen JP, Lee IT, Wang JS, Lin CH, Lin HJ, Sheu WH, Lee WL*, Hsiao TH*. (2021, Sep) Familial Hypercholesterolemia Genetic Variations and Long-Term Cardiovascular Outcomes in Patients with Hypercholesterolemia Who Underwent Coronary Angiography. Genes (Basel). 12(9):1413. doi: 10.3390/genes12091413. TCVGH-1077317C, TCVGH-1077323D, TCVGH-1087314C, TCVGH-1097315C, TCVGH1097330D, TCVGH-1107314C, TCVGH-VHCY1098605, TCVGH-1077331E, TCVGH-1087333E, TCVGH1097333E, TCVGH-1107333E  4.141 GENETICS & HEREDITY 77/191 3x3x5*0.9=40.5
35 Yu QY, Lu TP, Hsiao TH, Lin CH, Wu CY, Tzeng JY, Hsiao CK. (2021, Sep) An Integrative Co-localization (INCO) Analysis for SNV and CNV Genomic Features With an Application to Taiwan Biobank Data. Front Genet. 2021 Sep 8;12:709555. doi: 10.3389/fgene.2021.709555. eCollection 2021. MOST 106-2314-B-002 -097-MY3 (to Q-YY, T-PL, CH, and J-YT), MOST 109-2314- B-002-152 & 110-2314-B-002-078-MY3 (to T-PL and CH), and National Institutes of Health Grants P01 CA142538 (to J-YT
36 Chen YM, Chen HK, Wu BJ, Chen IC, Chen JP, Lin CH*, Hsiao TH*. (2021, Sep) Systemic lupus erythematosus and autoimmune features in chronic hospitalized patients with schizophrenia. Schizophr Res.237:166-173. doi: 10.1016/j.schres.2021.08.032. Online ahead of print. TCVGH-1087312 4.662 PSYCHIATRY 62/258 3x4x5*0.9=54
37 Chen YJ, Chen IC, Lin HJ, Lin YC, Chang JC, Chen YM, Hsiao TH, Chen PC, Lin CH. (2021 Aug) Association of ABCG2 rs2231142 Allele and BMI With Hyperuricemia in an East Asian Population. Front Genet. 12:709887. doi: 10.3389/fgene.2021.709887. eCollection 2021. TCVGH-1087312C
38 Tung H, Lin HJ, Chen PL, Lu TJ, Jhan PP, Chen JP, Chen YM, Wu CC, Lin YY, Hsiao TH*. (2021 Jul) Characterization of familial hypercholesterolemia in Taiwanese ischemic stroke patients. Aging (Albany NY). 27;13(15):19339-19351. doi: 10.18632/aging.203320. Epub 2021 Jul 27 NHRI109BCCO-MF-202013-01 5.955 CELL BIOLOGY 52/204 3x4x5=60
39 Hsiao, T.-H., Wang, R.C., Lu, T.-J., Shih, C.-H., Su, Y.-C., Tsai, J.-R., Jhan, P.-P., Lia, C.-S., Chuang, H.-N., Chang, K.-H. and Teng C.-L. (2021, Apr). Chemoresponse of de novo Acute Myeloid Leukemia to “7+3” Induction can Be Predicted by c-Myc-facilitated Cytogenetics. Front Pharmacol. 12:649267. doi: 10.3389/fphar.2021.649267. eCollection 2021.. TCVGH1093703C and TCVGH-YM1100107. 5.998 PHARMACOLOGY & PHARMACY 46/361 3x5x5=75
40 Mao Y.-C.,Chuang H.-H.,Shih C.-H.,Hsieh H.-G., Jiang Y.-U., Chiang L.-C., Lin W.-L., Hsiao T.-H.*,and Li P.-Y.* (2021, Apr). An investigation of conventional microbial culture for the Naja atra bite wound, and the comparison between culture-based 16S Sanger sequencing and 16S metagenomics of the snake oropharyngeal bacterial microbiota. PLOS Neglected Tropical Diseases. 15(4): e0009331. (109-2314-B075A-009) and Taichung Veterans General Hospital (TCVGH-1103901C 4.781 TROPICAL MEDICINE 2/28  3x6x5=90
41 Mu HY, Lu YL, Hsiao TH, Huang JH (2020, Dec). Microfluidic-based approaches for COVID-19 diagnosis. Biomicrofluidics. 2020 Dec 8;14(6):061504. doi: 10.1063/5.0031406. eCollection 2020 Nov.   https://aip.scitation.org/doi/pdf/10.1063/5.0031406
42 Kuo TC, Huang KY, Yang SC, Wu S, Chung WC, Chang YL, Hong TM, Wang SP, Chen HY, Hsiao TH*, Yang PC*. (2020, Sep). Monocarboxylate Transporter 4 Is a Therapeutic Target in Non-small Cell Lung Cancer with Aerobic Glycolysis Preference. Molecular Therapy Oncolytics. ;18:189-201 
43 Lin CC, Huang YK, Cho CF, Lin YS, Lo CC, Kuo TT, Tseng GC, Cheng WC, Chang WC, Hsiao TH, Lai LC, Shih JY, Liu YH, Chao KSC, Hsu JL, Lee PC, Sun X, Hung MC, Sher YP. (2020, Aug). Targeting positive feedback between BASP1 and EGFR as a therapeutic strategy for lung cancer progression. Theranostics.
44 Mu HY, Ou YC, Chuang HN, Lu TJ, Jhan PP, Hsiao TH*, Huang JH* (2020, Jun). Triple Selection Strategy for In Situ Labeling of Circulating Tumor Cells with High Purity and Viability toward Preclinical Personalized Drug Sensitivity Analysis. Advanced Biosystems, Jun;4(6):e2000013..
45 Brucker A, Lu W, Marceau West R, Yu QY, Hsiao CK, Hsiao TH, Lin CH, Magnusson PKE, Sullivan PF, Szatkiewicz JP, Lu TP, Tzeng JY. (2020, Mar). Association Test Using Copy Number Profile Curves (CONCUR) Enhances Power in Rare Copy Number Variant Analysis. PLoS Computational Biology, May 4;16(5):e1007797
46 Lin CY, Wu HY, Hsu YL, Cheng TR, Liu JH, Huang RJ, Hsiao TH, Wang CJ, Hung PF, Lan A, Pan SH, Chein RJ, Wong CH, Yang PC. (2020, Mar). Suppression of Drug-Resistant Non-Small-Cell Lung Cancer With Inhibitors Targeting Minichromosomal Maintenance Protein. Journal of medical chemistry, Mar 26;63(6):3172-3187.
47 Chou CW, Lin CH, Hsiao TH, Lo CC, Hsieh CY, Huang CC, Sher YP. (2019, Dec). Therapeutic Effects of Statins Against Lung Adenocarcinoma via p53 Mutant-Mediated Apoptosis. Scientific report, Dec 31;9(1):20403
48 Wang CC, Hsu YL, Chang CJ, Wang CJ, Hsiao TH, Pan SH. (2019, Dec). Inhibitor of DNA-Binding Protein 4 Suppresses Cancer Metastasis Through the Regulation of Epithelial Mesenchymal Transition in Lung Adenocarcinoma. Cancers, Dec 14;11(12):2021..
49 Lee MC1, Hsiao TH1, Chuang HN, Lee LW, Chi PL, Tsai HM, Mao CL, Hsu CP. (2020 Jan). Molecular profiling of thymoma with myasthenia gravis: Risk factors of developing myasthenia gravis in thymoma patients.. Lung Cancer , 2020 Jan;139:157-164
50 Chiu YC1, Hsiao TH1, Tsai JR, Wang LJ, Ho TC, Hsu SL, Teng CJ (2019, Oct). Integrating resistance functions to predict response to induction chemotherapy in de novo acute myeloid leukemia. . Eur J Haematol, 2019 Oct;103(4):417-425. 本人為第一作者. TCVGH‐1073702C and TCVGH‐1073703D 3.674 HEMATOLOGY 45/94 3x4x5*0.9=54
51 Tzeng CY, Chiang HY, Huang CC, Lin WS, Hsiao TH, Lin CH. (2019, Sep). The impact of pre-existing shoulder diseases and traumatic injuries of the shoulder on adhesive capsulitis in adult population: A population-based nested case-control study.. Medicine (Baltimore) , 2019 Sep; 98(39): e17204. TCVGH-1057329D, TCVGH-105G213, and TCVGH-NHRI10505
52 Yang UC, Hsiao TH, Lin CH, Lee WJ, Lee YS, Fann YC (2019, Jan). Integrative LHS for precision medicine research: A shared NIH and Taiwan CIMS experience. Learn Health Syst, 2019 Jan; 3(1): e10071.
53 Chiu YC1, Hsiao TH1, Wang LJ, Chen Y, Shao YJ. (2018, Dec). scdNet: a computational tool for single-cell differential network analysis.. BMC Systems Biology. 12(Suppl 8):124 .
54 Lin EP, Lin CH, Yang CY, Lu TP, Chang SN, Hsiao TH, Huang BT, Yu CJ, Chan KA, Yang PC. (2018, Dec). Population-Based Cohort Study Reveals Distinct Associations Between Female Lung Cancer and Breast Cancer in Taiwan.. JCO Clinical Cancer Informatics, 2018 Dec;2:1-14.. (Accepted).
55 Du L, Zhao Z, Suraokar M, Shelton SS, Ma X, Hsiao TH, Minna JD, Wistuba I, Pertsemlidis A. (2018, Jul). LMO1 functions as an oncogene by regulating TTK expression and correlates with neuroendocrine differentiation of lung cancer.. Oncotarget. . 2018 Jul 3; 9(51): 29601-29618.
56 Lin PY1, Hsiao TH1, Lu JY, Wong SH, Lu TP, Peck K, Takahashi T, Yang PC. (2018, Jul). Translating Gene Signatures Into a Pathologic Feature: Tumor Necrosis Predicts Disease Relapse in Operable and Stage I Lung Adenocarcinoma.. JCO precision oncology. 2018 Nov; 2: 1-13
57 Hsiao TH, Chiu YC, Chen YH, Hsu YC, Chen HH, Chuang EY, Chen Y. (2018, Feb). Utilizing Cancer – Functional Gene Set - Compound Networks to Identify Putative Drugs for Breast Cancer.. Combinatorial Chemistry & High Throughput Screening. 2018; 21(2): 74-83.
回頂端