Each infectious pathogen has its own special genetic composition. The center decodes the genetic composition of the pathogen through metagenomics next-generation sequencing (mNGS) and compares the sequenced genome with the reference sequences in the database. A single test can identify multiple pathogens in the sample.
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Sample collection
Collecting sample from infected paitnets. Sample types include blood, alveolar lavage fluid, tissue, etc. |
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DNA extration & Library preparation
The DNA/RNA in the sample is extracted through a validated extraction method, and optimized for the type of sample to prepare a sample library that can be used for sequencing. There is quality control throughout the process. |
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Sequencing
Using Shotgun next-generation sequencing technology to detect all genetic components in the sample and obtain sequence data.
Through sequencing of a large number of short sequence fragments simultaneously, a high-throughput gene decoding is achieved. |
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Analysis
Using the unique pathogen database (including pathogen sequence data of tens of thousands of cross-species), compare and analyze the sequenced data.
The process eliminates common source of bias in sequencing to ensure to eliminate background noise and improve the specificity of the analysis. |
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Reporting
The pathogen detection results after comparative analysis will be reviewed and sorted out by medical technicians and infectious disease physicians. Finally, a report will be issued to the patient's attending physician. |
Sample collection
Collecting sample from infected paitnets. Sample types include blood, alveolar lavage fluid, tissue, etc.