Director of Department


Yu-Cheng Hsieh, MD, PhD
E-mail:ychsieh@vghtc.gov.tw

Current Position
Director, Department of Medical Research,
Taichung Veterans General Hospital, Taichung, Taiwan
Professor of Medicine, National Yang Ming Chiao Tung
University School of Medicine, Taipei; and National Chung Hsin University College of Medicine, Taichung, Taiwan

Education
1989- 1996     MD, National Yang-Ming University School of Medicine, Taipei, Taiwan
2005- 2011      PhD, Institute of Clinical Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan
2011- 2012      Postdoctoral Research Fellow, Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, IN, USA (Dr. Peng-Sheng Chen’s lab)

Clinical Training
Jul. 1998- Jun. 2001    Resident training, Department of Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
Jul. 2001- Jun. 2003    Chief resident, Division of Cardiology, Taichung Veterans General Hospital, Taichung, Taiwan
Jul. 2003- present        Attending physician, Cardiovascular center, Taichung Veterans General Hospital, Taichung, Taiwan

University Appointment
Professor of Medicine, National Chung Hsin University College of Medicine, Taichung, Taiwan (2020~)
Professor of Medicine, National Yang Ming Chiao Tung University School of Medicine, Taipei, Taiwan (2020~)

Research Paper
(2023)
Chien YS, Weng CJ, Wu SJ, Li CH, Lin JC, Huang JL, Lin SF, Lin YJ, Hsieh YC*, Chen SA*. Levosimendan Attenuates Electrical Alternans and Prevents Ventricular Arrhythmia during Therapeutic Hypothermia in Isolated Rabbit Hearts. Heart Rhythm.2023 May;20(5):744-753. (*co-corresponding author)
Li GY, Chen YY, Lin YJ, Chien KL, Hsieh YC, Chung FP, Lo LW, Chang SL, Chao TF, Hu YF, Lin CY, Chen SA. Ablation of atrial fibrillation and dementia risk reduction during long-term follow-up: a nationwide population-based study. Europace. 2023 May 19;25(5):euad109.
Chen YY, Lin YJ, Hsieh YC, Chien KL, Lin CH, Chung FP, Chen SA. Atrial fibrillation as a contributor to the mortality in patients with dementia: A nationwide cohort study. Front Cardiovasc Med. 2023 Apr 3;10:1082795.
Lin CY, Chang TY, Hu YF, Hsieh YC, Chen YJ, Yeh HI, Lin YJ, Chang SL, Lo LW, Chao TF, Chung FP, Liao JN, Tuan TC, Chen SA.Epicardial electrical heterogeneity after amiodarone treatment increases vulnerability to ventricular arrhythmias under therapeutic hypothermia. PLoS One. 2023 Apr 20;18(4):e0282943.
Singh B, Hsieh YC, Liu YB, Lin KH, Joung B, Rodriguez DA, Chasnoits AR, Huang D, Zhang S, O'Brien JE, Lexcen DR, Cerkvenik J, Van Dorn B, Ching CK. Cardioverter-defibrillator reduces mortality risk in eligible ischemic and non-ischemic cardiomyopathy patients: Sub-analysis of the multi-center Improve SCA study. Indian Heart J. 2023 Mar-Apr;75(2):115-121.
Chin CG, Hsieh YC, Lin WS, Lin YJ, Chiou CW, Lin TH, Huang CL, Hung Y, Lin YK, Chang SL, Yeh TC, Lee HC, Lai WT, Hsieh MH.An open-label randomized noninferior study of generic name and brand name of propafenone for rhythm control in patients with paroxysmal atrial fibrillation. J Chin Med Assoc. 2023 May 1;86(5):472-478.

(2022)
Yugo D, Chen YY, Lin YJ*, Chien KL, Chang SL, Lo LW, Hu YF, Chao TF, Chung FP, LiaoJN, Chang TY, Lin CY, Tuan TC, Kuo L, Wu CI, Liu CM, Liu SH, Li CH, Hsieh YC*, Chen SA. Long-term Mortality and Cardiovascular Outcomes in Patients with Atrial Flutter after Catheter Ablation. Europace. 2022 Jul 15;24(6):970-978. (*co-corresponding author)
Li CH, Lo LW*, Jain A, Hsieh YC, Lin YJ, Chang SL, Chung FP, Hu YF, Chao TF, Liao JN, Chang TY, Lin CY, Lugtu IC, Ton AN, Liu SH, Cheng WH, Liu CM, Wu CI, Chen SA*. Patterns and Characteristics of SKYLINE-Lumipoint Feature in the Catheter Ablation of Atypical Atrial Flutter: Insight from a Novel Lumipoint Module of Rhythmia Mapping System. J Pers Med 2022 Jul 4;12(7):1102.
Wu SJ, Li CH*, Weng CJ, Lin JC, Chien YS, Chen YH, Lin CH, Hsieh YC*, Huang JL, Lo LW, Lin YJ , Chen SA. Efficacy of Cryoballoon Ablation for Atrial Fibrillation and Recurrence Predictors in an Asian Cohort. J Pers Med. 2022;12:732. (*co-corresponding author)
Lin JC, Li CH, ChenYY, Weng CJ, Chien YS, Wu SJ, Lo CP, Tien HC, Lin CH, Huang JL, Lin YJ, Hsieh YC*, Chen SA. Rhythm Control Better Prevents Dementia than Rate Control Strategies in Patients with Atrial Fibrillation-A Nationwide Cohort Study. J Pers Med. 2022;12:572. (*corresponding author)
Wu SJ, Hsieh YC*. Sudden cardiac death in heart failure with preserved ejection fraction: an updated review. Int J Arrhythm. 2022;23:7. (*corresponding author)
Wu SJ, Li CH, Lin JC, Weng CJ, Lin WW, Hsieh YC*. Detecting supraventricular tachycardia with smartwatches facilitates the decision for catheter ablation: A case series. Pacing Clin Electrophysiol. 2022 Jan;45(1):157-159. (*corresponding author)
Wu SJ, Cheng YT, Li CH, Weng CJ, Hsieh YC*, Chen SA. Leadless Pacemaker Implantation in a Patient with Dextrocardia and Situs Inversus: Tips and Tricks. Acta Cardiol Sin. 2022 Jan;38(1):103-105. (*corresponding author)
Lin CY, Chung FP, Nwe N, Hsieh YC, Li CH, Lin YJ, Chang SL, Lo LW, Hu YF, Tuan TC, Chao TF, Liao JN, Chang TY, Kuo L, Wu CI, Liu CM, Liu SH, Cheng WH, Chen SA. Impact of Amiodarone Therapy on the Ablation Outcome of Ventricular Tachycardia in Arrhythmogenic Right Ventricular Cardiomyopathy. J Clin Med. 2022 Dec 7;11(24):7265.
Liu CH, Lo LW, Chung FP, Chang SL, Hu YF, Lin YJ, Huang SC, Gan ST, Lin CY, Chao TF, Liao JN, Tuan TC, Liu CM, Shiu YC, Wu CI, Kuo L, Vicera JJB, Lugtu I, Li CH, Hsieh YC, Chen YJ, Chen SA. The impact of height on recurrence after index catheter ablation of paroxysmal atrial fibrillation. J Interv Card Electrophysiol. 2022 Sep;64(3):587-595
Chen YY, Kuo MJ, Chung FP, Lin YJ, Chien KL, Hsieh YC, Chang SL, Lo LW, Hu YF, Chao TF, Liao JN, Chang TY, Lin CY, Kuo L, Tuan TC, Wu CI, Liu CM, Liu SH, Li CH, Chen SA. Risks of Ventricular Tachyarrhythmia and Mortality in Patients with Amyloidosis - A Long-Term Cohort Study. Acta Cardiol Sin. 2022 Jul;38(4):464-474.
Li CH, Lo LW, Jain A, Hsieh YC, Lin YJ, Chang SL, Chung FP, Hu YF, Chao TF, Liao JN, Chang TY, Lin CY, Lugtu IC, Ton AN, Liu SH, Cheng WH, Liu CM, Wu CI, Chen SA. Patterns and Characteristics of SKYLINE-Lumipoint Feature in the Catheter Ablation of Atypical Atrial Flutter: Insight from a Novel Lumipoint Module of Rhythmia Mapping System. J Pers Med. 2022 Jul 4;12(7):1102.
Lin CY , Chung FP, Lin YJ* , Chang SL, Lo LW, Hu YF, Tuan TC, Chao TF, Liao JN, Chang TY, Wu CI, Liu CM, Liu SH, Huang JL, Hsieh YC, Chen SA. Clinical Significance of Structural Remodeling Concerning Substrate Characteristics and Outcomes in Arrhythmogenic Right Ventricular Cardiomyopathy. Heart Rhythm O2. 2022 May 5;3(4):422-429.
Wu CI, Lin YJ, Lee IH, Lo MT, Hsieh YC, Chen AY, Wang WK, Chang SL, Lo LW, Hu YF, Chung FP, Tuan TC, Chao TF, Liao JN, Hsieh WH, Chang TY, Lin CY, Feng AN, How CK, Chen SA. Using QRS loop descriptors to characterize the risk of sudden cardiac death in patients with structurally normal hearts. PLoS One. 2022 Feb 16;17(2):e0263894.

(2021)
Hsieh YC, Lin YJ, Lo MT, Chen YY, Lin CY, Lin C, Chung FP, Lo LW, Chang SL, Chao TF, Hu YF, Tuan TC, Liao JN, Wu CI, Liu CM, Vicera JJ B, Chen CC, Chin CG, Lugtu IC, Chen SA. Optimal Substrate Modification Strategies using Catheter Ablation in Patients with Persistent Atrial Fibrillation: 3‐Year Follow‐up Outcomes. J Cardiovasc Electrophysiol. 2021 Jun;32(6):1561-1571.
Tsai YN, Cheng WH, Chang YT, Hsiao YW, Chang TY, Hsieh YC, Lin YJ, Lo LW, Chao TF, Kuo MJ, Higa S, Chang SL, Chen SA. Mechanism of angiotensin receptor- neprilysin inhibitor in suppression of ventricular arrhythmia. J Cardiol. 2021 Oct;78(4):275-284.
Ching CK, Hsieh YC, Liu YB, Rodriguez DA, Kim YH, Joung B, Singh B, Huang D, Hussin A, Chasnoits AR, O'Brien JE, Cerkvenik J, Lexcen D, Van Dorn B, Zhang S. The mortality analysis of primary prevention patients receiving a cardiac resynchronization defibrillator (CRT-D) or implantable cardioverter-defibrillator (ICD) according to guideline indications in the improve SCA study. J Cardiovasc Electrophysiol. 2021 Aug;32(8):2285-2294.
Chen YY, Lin YJ, Chien KL, Chao TF, Lo LW, Chang SL, Chung FP, Lin CY, Chang TY, Kuo L, Hsieh YC, Li CH, Chen SA. Novel model-based point scoring system for predicting stroke risk in atrial fibrillation patients: Results from a nationwide cohort study with validation. Int J Cardiol Heart Vasc. 2021 Apr 28;34:100787.
Tsai YN, Hsiao YW, Lin SF, Chan YH, Hsieh YC, Tang WH, Lee AS, Huang YT, Li HY, Chao TF, Higa S, Wu TJ, Chang SL* and Chen SA*. Proinflammatory Cytokine Modulates Intracellular Calcium Handling and Enhances Ventricular Arrhythmia Susceptibility. Front Cardiovasc Med. 2021 Mar 16;8:623510.

(2020)
Hsieh YC*. Editorial to "Atrial fibrillation and the risk of 30-day incident thromboembolic events and mortality in adults ≥50 years with COVID-19". J Arrhythm. 2020 Dec 3;10.1002/ joa3.12477. (*corresponding author)
Hsieh YC*, Chen YY, Chien KL, Chung FP, Lo LW, Chang SL, Chao TF, Hu YF, Lin CY, Tuan TC, Liao JN, Lin YJ, Chen SA. Catheter ablation of atrial fibrillation reduces the risk of dementia and hospitalization during a very long-term follow-up. Int J Cardiol. 2020 Apr 1;304:75-81. (*corresponding author)
Hsieh YC*, Hsieh WH, Li CH, Liao YC, Lin JC, Weng CJ, Lo MT, Tuan TC, Lin SF, Yeh HI, Huang JL, Haugan K, Larsen BD, Lin YJ, Lin WW, Wu TJ, Chen SA. Ventricular divergence correlates with epicardial wavebreaks and predicts ventricular arrhythmia in isolated rabbit hearts during therapeutic hypothermia. PLoS One. 2020 Feb 21;15(2):e0228818. (*corresponding author)
Hsieh YC*, Liao YC, Li CH, Lin JC, Weng CJ, Lin CC, Lo CP, Huang KC, Huang JL,  Lin CH, Wang JS, Wu TJ, Sheu W H-H. Hypoglycemic Episodes Increase the Risk of Ventricular Arrhythmia and Sudden Cardiac Arrest in Patients with Type 2 Diabetes- A Nationwide Cohort Study. Diabetes Metab Res Rev. 2020 Feb;36(2):e3226. (*corresponding author)
Huang HT, Chen WJ, Li CH, Huang JL, Hsieh YC*, Wu TJ. Early Recognition of Electrocardiographic Lambda-wave ST Elevation during Propofol Infusion Prevents Ventricular Tachyarrhythmia and Cardiac Arrest. Acta Cardiol Sin. 2020 Sep;36(5):517-519. (*corresponding author)
Chiang KF, Wang CY, Huang JL, Hsieh YC. Transient left bundle branch block and poor atrioventricular conduction during ablation of accessory pathway at the left ventricle. J Arrhythm. 2020 Oct 23;36(6):1092-1095.
Holbrook R, Higuera L, Wherry K, Phay D, Hsieh YC, Lin KH, Liu YB. Implantable cardioverter defibrillator therapy is cost effective for primary prevention patients in Taiwan: An analysis from the Improve SCA trial. PLoS One. 2020 15(11):e0241697.

(2018)
Weng CJ, Li CH, Liao YC, Lin CC, Lin JC, Chang SL, Lo CP, Huang KC, Huang JL, Lin CH, Hsieh YC*, Wu TJ. Data for Rate versus Rhythm Control Strategy on Stroke and Mortality in Patients with Atrial Fibrillation. Data Brief. 2018 Sep 6;20:1279-1285. (*corresponding author)
Weng CJ, Li CH, Liao YC, Lin CC, Lin JC, Chang SL, Lo CP, Huang KC, Huang JL, Lin CH, Hsieh YC*, Wu TJ. Rhythm Control Better Prevents Stroke and Mortality than Rate Control Strategies in Patients with Atrial Fibrillation - A Nationwide Cohort Study. Int J Cardiol. 2018 154-159. (*corresponding author)
Liu CM, Lin CY, Chang SL, Lin YJ, Lo LW, Hu YF, Chao TF, Chung FP, Tuan TC, Liao JN, Chen YY, Te AL D, Yamada S, Kuo L, Li HY, Chang TY, Hoang QM, Salim S, Ba VV, Vicera JJ B, Wu CI, Chuang CM, Huang TC, Hsieh YC*, Chen SA. Intermediate Pause at Daytime Is Associated with Increased Cardiovascular Risk and Mortality- A 8-Year Cohort Study. J Am Heart Assoc. 2018;7(12). pii: e009034. (*corresponding author)
Chan CW, Yu CL, Lin JC, Hsieh YC*, Lin CC, Hung CY, Li CH, Liao YC, Lo CP, Huang JL, Lin CH, Wu TJ. Glitazones and Alpha-glucosidase Inhibitors as the Second-line Oral Anti-diabetic Agents Added to Metformin Reduce Cardiovascular Risk in Type 2 Diabetes Patients: A Nationwide Cohort Observational Study. Cardiovasc Diabetol. 2018;17(1):20 (*corresponding author)
Chang SL, Hsiao YW, Tsai YN, Lin SF, Liu SH, Lin YJ, Lo LW, Chung FP, Chao TF, Hu YF, Tuan TC, Liao JN, Hsieh YC, Wu TJ, Higa S, Chen SA. Interleukin-17 enhances cardiac ventricular remodeling via activating MAPK pathway in ischemic heart failure. J Mol Cell Cardiol. 2018 Aug 8;122:69-79.