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Div. Neuromuscular Disease

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Updated 2022/12/6 10:04:52
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Neuromuscular disorders
    Neuromuscular disorders division, set up in 2013, is a part of Neurological Institute, supervised now by the Chief Physician, Chou Chi-
    Hsiang.

  • Neuromuscular diseases encompass a broad spectrum of disorders, which may involve (1) motor neurons of the spinal cord, (2) motor and sensory nerves in the limbs, for example, entrapment neuropathy and polyneuropathy (3) muscle and the (4) transmission between nerve and muscle, for example, myasthenia gravis. Patient usually presented with limbs weakness or numbness.
  • Entrapment neuropathy: Carpal tunnel syndrome is most common (usually presented with fingers numbness, clumsiness of hands movement and awaken due to hands discomfort).
  • Polyneuropathy: Presented with four limbs weakness and numbness, distal onset symptoms, could be related to genetic disorders or acquired diseases.
  • Neuromuscular junction disorders: myasthenia gravis, for instance, patients mostly complaint eyelids ptosis, diplopia, dysphagia or limbs weakness, usually improved after resting.
  • Muscle disorders: Usually presented with proximal limbs weakness, like difficult raising arms up or stand up from squat position, including dermatomyositis, polymyositis, metabolic muscular disorders or genetic related muscular dystrophy.
  • Motor neuron diseases: In adult, usually present with limbs weakness, muscle atrophy and fasciculation, but no sensory discomfort (like pain or numbness), for example, ALS (amyotrophic lateral sclerosis ).
Movement disorders
Sub-specialists of Movement disorders are also belonging to Division of Neuromuscular Disorders. The former Division Chief was professor Chang Ming-Hong, now is Guo Yi-Jen.
Parkinsonism and Parkinson’s disease are the most common movement disorders. Besides parkinsonism syndrome, involuntary movement and other bradykinesia syndrome, such tremor, myoclonus, chorea and dystonia are also included. We also provide consultation and genetic examinations of spinocerebellar atrophy and other familial movement disorders. Botulinium shot for dystonia are also provided in our clinic.
Take Parkinson’s disease for example:
  • Patient with Parkinson’s disease usually present with rigidity, bradykinesia and progressive limbs tremor. We discriminate Parkinson’s disease from Parkinsonism according to clinical presentation, respond to L-dopa, MRI and Tc-99m TRODAT-SPECT.
  •  We had formed a multidisciplinary team including neurosurgeon and neurologist, provide Deep Brain Stimulation (DBS) surgery for suitable patients with Parkinson’s disease. We use frameless stereotactic guided neurosurgery which not only reduce the discomfort of patients substantially, but also increased the surgical precision. Therefore, the efficacy to improve patients’ quality of life significantly increased
Our Faculties
Physicians:
    Chou Chi-Hsiang, Chief Physician of the Neuromuscular disorders (and movement disorders) division
    Guo Yi-Jen, Chief Physician of the Movement Disorders
    Chang Ming-Hong, the former Head of Neurological Institute
    Chou Cheng-Ta, Attending physician
    Fang Ting-Chun, Attending physician
    Chao Yi-Ting, Attending physician
Case Manager:
    Chen Pin-Jing
Technician:
    Tsai Chi-Wei
Services and features
(1) Nerve conduction study and Electromyography
A. Clinical Significance:
    Nerve conduction study records the conditions of motor and sensory components of peripheral nerves. Electromyography records the muscle electric activities. Both have important value for peripheral nerve function evaluation. In clinical practice, the electrode plates are placed on the skin and electrode needle are inserted in the muscle to measure and record. It can be uncomfortable at times, but don't worry, it's harmless and even young children can be tested. During clod weather, patients should arrive at the examination room 15 to 20 minutes earlier to warm their hands and feet. This examination rarely takes more than 30 to 40 minutes.

B. Clinical Applications:
1. Detect peripheral neuropathy.
2. To study lesions at the neuromuscular junction or in the muscle itself.
3. Survey neurological and muscular dysfunction caused by metabolic diseases.
4. Detect the possibility of malingering'
5. Differentiate the lesion origin is central or peripheral nervous system.

C. Preparation before inspection:
Please wear loose-fitting clothing and do not apply ointments or lotions on your hands or feet.

(2) Evoked potential
A. Clinical Significance:
Evoked potential examination can be divided into several types of sensory stimuli (mainly including: visual, auditory, and somatosensory) are used to evaluate your nervous system conduction pathways to find lesion locations.

B. Clinical Applications:
Visual evoked potential (VEP) is to detect the response of the visual conduction pathway through the change of the image on the computer screen.
Auditory evoked potential (AEP) is to stimulate the auditory pathway with sound signals, and record the responses of the auditory nerve, brainstem, and other related parts.
Somatosensory evoked potential (SSEP) is the use of low-intensity electric current to stimulate the sensory nerves of the hands or feet, to detect whether there is any abnormality in the somatosensory conduction pathway.

C. Preparation before inspection
Patients’ hair must be washed before the examination, do not use hairspray.
For patients receiving visual evoked potentials, if they have eyeglasses, please wear eyeglasses during the examination.
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